The lineup has been unveiled for the 2022 edition of the George Street Festival.
- Thursday, July 28 – soon to be revealed!
- Friday, July 29 – The Tea Party and Sam Roberts Band w/ Women of Rock
- Saturday, July 30 – Family-friendly matinee and Kitchen Party with The Masterless Men, The Navigators, Celtic Connection, and more!
- Sunday, July 31 – Alan Doyle and Fortunate Ones w/ Kellie Loder
- Monday, August 1 – Arkells and Snotty Nose Rez Kids
- Tuesday, August 2 – Shanneyganock and Signal Hill w/ Rum Ragged
- Wednesday, August 3 – Brett Kissel and Meghan Patrick w/ Justin Fancy